The Therapeutic Potential of a Strategy to Prevent Acute Myeloid Leukemia Stem Cell Reprogramming in Older Patients

Acute myeloid leukemia (AML) is the most common and incurable subtype. Despite extensive research into disease’s intricate molecular mechanisms, effective treatments or expanded diagnostic prognostic markers for AML have not yet been identified. The morphological, immunophenotypic, cytogenetic, biomolecular, clinical characteristics of patients are complex. Leukemia stem cells (LSCs) consist hematopoietic (HSCs) cancer transformed by a complex, finely-tuned interaction that causes complexity AML. Microenvironmental regulation LSCs dormancy therapeutic implications identifying targeting due to their significance in pathogenesis discussed this review. It essential perceive relationship between niche HSCs, which together cause progression Notably, methylation well-known epigenetic change significant AML, our data also reveal microRNAs unique factor LSCs. Multiple-targeted approaches reduce risk factors, such as administration natural compounds elimination local LSCs, may prevent potentially fatal relapses. Furthermore, survival analysis overlapping genes revealed specific targets had effects on prognosis patients. We predict multiple-targeted herbal products modification governed different mechanisms could Thus, these strategies can facilitate incorporation medicine advanced drug discovery development processes achievable with Network Pharmacology research.